We were thrilled and excited to come across this newly presented Synergo® data at the last Auro National Congress. Dr. Canepa, Dr. Campodonico and team presented their long term outcomes of treatment in Genova centres, Italy.
TEN YEARS EXPERIENCE WITH INTRAVESICAL THERMO-CHEMOTHERAPY MMC 40MG FOR NON MUSCLE INVASIVE BLADDER CANCER HIGH/INTERMEDIATE RISK
G. Canepa1, F. Campodonico1, S. Tamagno1, C. Introini2, M. Puntoni31 E.O. Ospedali Galliera, S.C. Urologia (Genova) 2 Ospedale Evangelico Internazionale, S.C. Urologia (Genova Voltri) 3 E.O. Ospedali Galliera, Direzione Scientifica e Biostatistica (Genova)
Aim of the study: evaluate the long-term experience on a treatment combining intravesical hyperthermia with Mytomicin C (HT-MMC) delivered with the Synergo® device.
More than 1600 treatments performed since 2004
146 Intermediate and High-risk NMIBC patients
37/146 patients reported a recurrence and 14/146 patients presented a progression.
The Recurrence Free Survival at 1, 2 and 5 years was 89.6%, 79.2 and 68.3 respectively.
Progression Free Survival at 1, 2 and 5 years was 98%, 96.2 and 83.7 respectively.
The number of treatment sessions for each patients were 10.4+/- 4.7 with a median of 11 sessions (Range 4-31). The time of exposure over 42°C was 37.4+/-7.4 mins. and the mean temperature was 42.0+/-0.8°C. The safety profile showed mainly grade 1 and 2 side effects. Ten patients complained grade 3 side-effects, including 1 patient bladder spasms/pain during treatment, 3 patients dysuria and 6 patients urgency after treatment.
Presented at: XXIII Congresso Nazionale Auro May 2016
Solve.Care is a global healthcare platform which aims to redefine care coordination, improve access to care, empower the consumer with information, reduce benefit administration costs, as well as eliminate fraud and waste from healthcare and benefit administration around the world.
ReplyDelete